Dr. Ayşegül Öktem
Eğitim
- Doktora, Groningen Üniversitesi, Groningen, Hollanda
- Yüksek Lisans, Orta Doğu Teknik Üniversitesi, Moleküler Biyoloji ve Genetik
- Lisans, Orta Doğu Teknik Üniversitesi, Moleküler Biyoloji ve Genetik
Araştırma Alanları
- Mikrobiyal hücre fabrikaları
- Hücre mühendisliği
- Rekombinant gıda enzimi üretimi
- Mikrobiyal fermentasyon
- Sürdürülebilir fermentasyon teknikleri
- Bakteriyel sistemlerin stres fizyolojisi
Son Yayınlar
Öktem A., Yokoyama, K., Wu Y., Grilli F., Maaß S., Ishikawa S., Yotsuya M., Sato R., van
Dijl, J. M. *, Yoshida K.* (2026). Effects of breathing vessel culture on enzyme secretion
by a genome-reduced strain of Bacillus subtilis. Microbial Cell Factories. 25(53). https://doi.org/10.1186/s12934-026-02942-x
Yoshida, K., Yokoyama, K., Öktem, A., Ishikawa, S., van Dijl, J. M., Yotsuya, M., & Sato,
R. (2024). Bacillus subtilis grown in a “breathing” vessel without sparger aeration.
Bioscience Biotechnology and Biochemistry. 88(11), 1389-1393.
https://doi.org/10.1093/bbb/zbae120
Aguilar Suárez, R., Kohlstedt, M.*, Öktem, A.*, Neef, J., Wu, Y., Ikeda, K., ... van Dijl,
J. M. (2024). Metabolic profile of the genome-reduced bacillus subtilis strain iig-bs-27-
39: An attractive chassis for recombinant protein production. ACS Synthetic Biology. 13(7), 2199-2214. https://doi.org/10.1021/acssynbio.4c00254
Öktem, A., Pranoto D. A., van Dijl J. M. (2024) Post-translational secretion stress
regulation in Bacillus subtilis is controlled by intra- and extracellular proteases. New
Biotechnology. 79, 71-81. https://doi.org/10.1016/j.nbt.2023.12.009
Öktem A., Núñez-Nepomuceno D., Ferrero-Bordera B., Walgraeve J., Seefried M.,
Gesell-Salazar M., Maaß S., Becher D., Mäder U., Völker U.*, van Dijl J. M.* (2023)
Enhancing bacterial fitness and recombinant enzyme yield by engineering the quality
control protease HtrA of Bacillus subtilis. Microbiology Spectrum. e01778-
23. https://doi.org/10.1128/spectrum.01778-23
Rettenbacher, L. A.*, Arauzo-Aguilera, K.*, Buscajoni, L.*, Castillo-Corujo, A.*, Ferrero-
Bordera, B.*, Kostopoulou, A.*, Moran-Torres, R.*, Núñez-Nepomuceno, D.*, Öktem,
A.*, Palma, A.*, Pisent, B.*, Puricelli, M.*, Schilling, T.*, Tungekar, A. A.*, Walgraeve,
J.*, Humphreys, D., von der Haar, T., Gasser, B., Mattanovich, D., … van Dijl, J. M.
(2022). Microbial protein cell factories fight back? Trends in Biotechnology. 40(5), 576–590. https://doi.org/10.1016/j.tibtech.2021.10.003